Favipiravir Pharmacokinetics in Nonhuman Primates and Insights for Future Efficacy Studies of Hemorrhagic Fever Viruses

Favipiravir is an RNA polymerase inhibitor that showed strong antiviral efficacy in vitro and in small-animal models of several viruses responsible for hemorrhagic fever (HF), including Ebola virus. The aim of this work was to characterize the complex pharmacokinetics of favipiravir in nonhuman prim...

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Publicat a:Antimicrob Agents Chemother
Autors principals: Madelain, Vincent, Guedj, Jérémie, Mentré, France, Nguyen, Thi Huyen Tram, Jacquot, Frédéric, Oestereich, Lisa, Kadota, Takumi, Yamada, Koichi, Taburet, Anne-Marie, de Lamballerie, Xavier, Raoul, Hervé
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2016
Matèries:
Antiviral Agents
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5192134/
https://ncbi.nlm.nih.gov/pubmed/27736754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01305-16
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