Modeling Favipiravir Antiviral Efficacy Against Emerging Viruses: From Animal Studies to Clinical Trials

In 2014, our research network was involved in the evaluation of favipiravir, an anti‐influenza polymerase inhibitor, against Ebola virus. In this review, we discuss how mathematical modeling was used, first to propose a relevant dosing regimen in humans, and then to optimize its antiviral efficacy i...

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Detalhes bibliográficos
Publicado no:CPT Pharmacometrics Syst Pharmacol
Main Authors: Madelain, Vincent, Mentré, France, Baize, Sylvain, Anglaret, Xavier, Laouénan, Cédric, Oestereich, Lisa, Nguyen, Thi Huyen Tram, Malvy, Denis, Piorkowski, Géraldine, Graw, Frederik, Günther, Stephan, Raoul, Hervé, de Lamballerie, Xavier, Guedj, Jérémie
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
Assuntos:
Review
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7239338/
https://ncbi.nlm.nih.gov/pubmed/32198838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/psp4.12510
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