Favipiravir Pharmacokinetics in Nonhuman Primates and Insights for Future Efficacy Studies of Hemorrhagic Fever Viruses

Favipiravir is an RNA polymerase inhibitor that showed strong antiviral efficacy in vitro and in small-animal models of several viruses responsible for hemorrhagic fever (HF), including Ebola virus. The aim of this work was to characterize the complex pharmacokinetics of favipiravir in nonhuman prim...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Madelain, Vincent, Guedj, Jérémie, Mentré, France, Nguyen, Thi Huyen Tram, Jacquot, Frédéric, Oestereich, Lisa, Kadota, Takumi, Yamada, Koichi, Taburet, Anne-Marie, de Lamballerie, Xavier, Raoul, Hervé
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2016
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5192134/
https://ncbi.nlm.nih.gov/pubmed/27736754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01305-16
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