Novel Dithiolane-Based Ligands Combining Sigma and NMDA Receptor Interactions as Potential Neuroprotective Agents

[Image: see text] Sigma receptors (SRs) are recognized as valuable targets for the treatment of neurodegenerative disorders. A series of novel SRs ligands were designed by combining key pharmacophoric amines (i.e., benzylpiperidine or benzylpiperazine) with new 1,3-dithiolane-based heterocycles and...

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Publicat a:ACS Med Chem Lett
Autors principals: Franchini, Silvia, Linciano, Pasquale, Puja, Giulia, Tait, Annalisa, Borsari, Chiara, Denora, Nunzio, Iacobazzi, Rosa Maria, Brasili, Livio, Sorbi, Claudia
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2020
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7236556/
https://ncbi.nlm.nih.gov/pubmed/32435421
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.0c00129
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