TSPO Ligand-Methotrexate Prodrug Conjugates: Design, Synthesis, and Biological Evaluation

The 18-kDa translocator protein (TSPO) is a potential mitochondrial target for drug delivery to tumors overexpressing TSPO, including brain cancers, and selective TSPO ligands have been successfully used to selectively deliver drugs into the target. Methotrexate (MTX) is an anticancer drug of choice...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Int J Mol Sci
Päätekijät: Laquintana, Valentino, Denora, Nunzio, Cutrignelli, Annalisa, Perrone, Mara, Iacobazzi, Rosa Maria, Annese, Cosimo, Lopalco, Antonio, Lopedota, Angela Assunta, Franco, Massimo
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: MDPI 2016
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4926499/
https://ncbi.nlm.nih.gov/pubmed/27322261
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms17060967
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