TSPO Ligand-Methotrexate Prodrug Conjugates: Design, Synthesis, and Biological Evaluation

The 18-kDa translocator protein (TSPO) is a potential mitochondrial target for drug delivery to tumors overexpressing TSPO, including brain cancers, and selective TSPO ligands have been successfully used to selectively deliver drugs into the target. Methotrexate (MTX) is an anticancer drug of choice...

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Vydáno v:Int J Mol Sci
Hlavní autoři: Laquintana, Valentino, Denora, Nunzio, Cutrignelli, Annalisa, Perrone, Mara, Iacobazzi, Rosa Maria, Annese, Cosimo, Lopalco, Antonio, Lopedota, Angela Assunta, Franco, Massimo
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4926499/
https://ncbi.nlm.nih.gov/pubmed/27322261
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms17060967
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