TSPO Ligand-Methotrexate Prodrug Conjugates: Design, Synthesis, and Biological Evaluation

The 18-kDa translocator protein (TSPO) is a potential mitochondrial target for drug delivery to tumors overexpressing TSPO, including brain cancers, and selective TSPO ligands have been successfully used to selectively deliver drugs into the target. Methotrexate (MTX) is an anticancer drug of choice...

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Detaylı Bibliyografya
Yayımlandı:Int J Mol Sci
Asıl Yazarlar: Laquintana, Valentino, Denora, Nunzio, Cutrignelli, Annalisa, Perrone, Mara, Iacobazzi, Rosa Maria, Annese, Cosimo, Lopalco, Antonio, Lopedota, Angela Assunta, Franco, Massimo
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: MDPI 2016
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4926499/
https://ncbi.nlm.nih.gov/pubmed/27322261
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms17060967
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