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A Medicinal Chemistry-Driven Approach Identified the Sterol Isomerase EBP as the Molecular Target of TASIN Colorectal Cancer Toxins
TASIN (Truncated APC-Selective Inhibitors) compounds are selectively toxic to colorectal cancer cells with APC mutations, although their mechanism of action remains unknown. Here, we found that TASINs inhibit three enzymes in the post-squalene cholesterol biosynthetic pathway including EBP, DHCR7, a...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | J Am Chem Soc |
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| Κύριοι συγγραφείς: | , , , , , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
2020
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7236545/ https://ncbi.nlm.nih.gov/pubmed/32163279 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.9b13407 |
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