A Medicinal Chemistry-Driven Approach Identified the Sterol Isomerase EBP as the Molecular Target of TASIN Colorectal Cancer Toxins

TASIN (Truncated APC-Selective Inhibitors) compounds are selectively toxic to colorectal cancer cells with APC mutations, although their mechanism of action remains unknown. Here, we found that TASINs inhibit three enzymes in the post-squalene cholesterol biosynthetic pathway including EBP, DHCR7, a...

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Detalhes bibliográficos
Publicado no:J Am Chem Soc
Main Authors: Theodoropoulos, Panayotis C., Wang, Wentian, Budhipramono, Albert, Thompson, Bonne M., Madhusudhan, Nikhil, Mitsche, Matthew A., McDonald, Jeffrey G., De Brabander, Jef K., Nijhawan, Deepak
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7236545/
https://ncbi.nlm.nih.gov/pubmed/32163279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.9b13407
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