5,6-Dihydroxypyrimidine Scaffold to Target HIV-1 Nucleocapsid Protein

[Image: see text] The HIV-1 nucleocapsid (NC) protein is a small basic DNA and RNA binding protein that is absolutely necessary for viral replication and thus represents a target of great interest to develop new anti-HIV agents. Moreover, the highly conserved sequence offers the opportunity to escap...

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Gepubliceerd in:ACS Med Chem Lett
Hoofdauteurs: Malancona, Savina, Mori, Mattia, Fezzardi, Paola, Santoriello, Marisabella, Basta, Andreina, Nibbio, Martina, Kovalenko, Lesia, Speziale, Roberto, Battista, Maria Rosaria, Cellucci, Antonella, Gennari, Nadia, Monteagudo, Edith, Di Marco, Annalise, Giannini, Alessia, Sharma, Rajhans, Pires, Manuel, Real, Eleonore, Zazzi, Maurizio, Dasso Lang, Maria Chiara, De Forni, Davide, Saladini, Francesco, Mely, Yves, Summa, Vincenzo, Harper, Steven, Botta, Maurizio
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Chemical Society 2020
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7236274/
https://ncbi.nlm.nih.gov/pubmed/32435383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.9b00608
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