Synthesis of Novel G Factor or Chloroquine-Artemisinin Hybrids and Conjugates with Potent Antiplasmodial Activity

[Image: see text] A series of novel hybrids of artemisinin (ART) with either a phytormone endoperoxide G factor analogue (GMeP) or chloroquine (CQ) and conjugates of the same compounds with the polyamines (PAs), spermidine (Spd), and homospermidine (Hsd) were synthesized and their antiplasmodial act...

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Publicado no:ACS Med Chem Lett
Main Authors: Pepe, Dionissia A., Toumpa, Dimitra, André-Barrès, Christiane, Menendez, Christophe, Mouray, Elisabeth, Baltas, Michel, Grellier, Philippe, Papaioannou, Dionissios, Athanassopoulos, Constantinos M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2020
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7236259/
https://ncbi.nlm.nih.gov/pubmed/32435406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.9b00669
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