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Harmine Is a Potent Antimalarial Targeting Hsp90 and Synergizes with Chloroquine and Artemisinin

Previous studies have shown an antimalarial effect of total alkaloids extracted from leaves of Guiera senegalensis from Mali in West Africa. We independently observed that the beta-carboline alkaloid harmine obtained from a natural product library screen inhibited Plasmodium falciparum heat shock pr...

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Autors principals: Shahinas, Dea, MacMullin, Gregory, Benedict, Christan, Crandall, Ian, Pillai, Dylan R.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3421604/
https://ncbi.nlm.nih.gov/pubmed/22615284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00328-12
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