The constitutive androstane receptor and pregnane X receptor in the brain

Since their discovery, the orphan nuclear receptors constitutive androstane receptor (CAR;NR1I3) and pregnane X receptor (PXR;NR1I2) have been regarded as master regulators of drug disposition and detoxification mechanisms. They regulate the metabolism and transport of endogenous mediators and xenob...

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Bibliographic Details
Published in:Br J Pharmacol
Main Authors: Torres‐Vergara, Pablo, Ho, Yu Siong, Espinoza, Francisca, Nualart, Francisco, Escudero, Carlos, Penny, Jeffrey
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2020
Subjects:
Review Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7236070/
https://ncbi.nlm.nih.gov/pubmed/32201941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.15055
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