Structural and Functional Similarity of Amphibian Constitutive Androstane Receptor with Mammalian Pregnane X Receptor

The nuclear receptors and xenosensors constitutive androstane receptor (CAR, NR1I3) and pregnane X receptor (PXR, NR1I2) induce the expression of xenobiotic metabolizing enzymes and transporters, which also affects various endobiotics. While human and mouse CAR feature a high basal activity and low...

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Main Authors: Mathäs, Marianne, Burk, Oliver, Gödtel-Armbrust, Ute, Herlyn, Holger, Wojnowski, Leszek, Windshügel, Björn
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2014
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4010427/
https://ncbi.nlm.nih.gov/pubmed/24797902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0096263
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