O11.3. SYNAPTIC MARKER PROTEIN SV2A IS REDUCED IN SCHIZOPHRENIA IN VIVO AND UNAFFECTED BY ANTIPSYCHOTICS IN RATS

BACKGROUND: The synaptic dysfunction hypothesis of schizophrenia is supported by multiple lines of evidence. However, in vivo evidence is lacking. Moreover, it is not known if antipsychotics alter synaptic protein levels. We addressed this in a combined clinical study using [11C]UCB-J, a positron em...

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Pubblicato in:Schizophr Bull
Autori principali: Chika Onwordi, Ellis, Halff, Els, Whitehurst, Thomas, Mansur, Ayla, Cotel, Marie-Caroline, Wells, Lisa, Creeney, Hannah, Bonsall, David, Rogdaki, Maria, Shatalina, Ekaterina, Reis Marques, Tiago, Rabiner, Eugenii, Gunn, Roger, Natesan, Sridhar, Vernon, Anthony, Howes, Oliver D
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2020
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Oral Session: Digital Health/Methods
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7233999/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/schbul/sbaa028.063
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