The relationship between synaptic density marker SV2A, glutamate and N-acetyl aspartate levels in healthy volunteers and schizophrenia: a multimodal PET and magnetic resonance spectroscopy brain imaging study

Glutamatergic excitotoxicity is hypothesised to underlie synaptic loss in schizophrenia pathogenesis, but it is unknown whether synaptic markers are related to glutamatergic function in vivo. Additionally, it has been proposed that N-acetyl aspartate (NAA) levels reflect neuronal integrity. Here, we...

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Publicat a:Transl Psychiatry
Autors principals: Onwordi, Ellis Chika, Whitehurst, Thomas, Mansur, Ayla, Statton, Ben, Berry, Alaine, Quinlan, Marina, O’Regan, Declan P., Rogdaki, Maria, Marques, Tiago Reis, Rabiner, Eugenii A., Gunn, Roger N., Vernon, Anthony C., Natesan, Sridhar, Howes, Oliver D.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2021
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8290006/
https://ncbi.nlm.nih.gov/pubmed/34282130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41398-021-01515-3
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