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Entropy Hotspots for the Binding of Intrinsically Disordered Ligands to a Receptor Domain
Proline-rich motifs (PRMs) are widely used for mediating protein-protein interactions with weak binding affinities. Because they are intrinsically disordered when unbound, conformational entropy plays a significant role for the binding. However, residue-level differences of the entropic contribution...
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| Publicat a: | Biophys J |
|---|---|
| Autors principals: | , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
The Biophysical Society
2020
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7231926/ https://ncbi.nlm.nih.gov/pubmed/32311315 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2020.03.026 |
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