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Entropy Hotspots for the Binding of Intrinsically Disordered Ligands to a Receptor Domain

Proline-rich motifs (PRMs) are widely used for mediating protein-protein interactions with weak binding affinities. Because they are intrinsically disordered when unbound, conformational entropy plays a significant role for the binding. However, residue-level differences of the entropic contribution...

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書目詳細資料
發表在:Biophys J
Main Authors: Shi, Jie, Shen, Qingliang, Cho, Jae-Hyun, Hwang, Wonmuk
格式: Artigo
語言:Inglês
出版: The Biophysical Society 2020
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7231926/
https://ncbi.nlm.nih.gov/pubmed/32311315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2020.03.026
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