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Combining sequence data from multiple studies: impact of analysis strategies on rare variant calling and association results
Individual sequencing studies often have limited sample sizes and so limited power to detect trait associations with rare variants. A common strategy is to aggregate data from multiple studies. For studying rare variants, jointly calling all samples together is the gold standard strategy but can be...
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| Vydáno v: | Genet Epidemiol |
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| Hlavní autoři: | , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2019
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7231418/ https://ncbi.nlm.nih.gov/pubmed/31520493 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/gepi.22261 |
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