Identification of PP2A and S6 Kinase as Modifiers of Leucine-Rich Repeat Kinase-Induced Neurotoxicity

Mutations in LRRK2 are currently recognized as the most common monogenetic cause of Parkinsonism. The elevation of kinase activity of LRRK2 that frequently accompanies its mutations is widely thought to contribute to its toxicity. Accordingly, many groups have developed LRRK2-specific kinase inhibit...

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Bibliographische Detailangaben
Veröffentlicht in:Neuromolecular Med
Hauptverfasser: Sim, Joan Poh Ling, Ziyin, Wang, Basil, Adeline Henry, Lin, Shuping, Chen, Zhongcan, Zhang, Chengwu, Zeng, Li, Cai, Yu, Lim, Kah-Leong
Format: Artigo
Sprache:Inglês
Veröffentlicht: Springer US 2019
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Original Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7230064/
https://ncbi.nlm.nih.gov/pubmed/31664682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12017-019-08577-z
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