Identification of PP2A and S6 Kinase as Modifiers of Leucine-Rich Repeat Kinase-Induced Neurotoxicity

Mutations in LRRK2 are currently recognized as the most common monogenetic cause of Parkinsonism. The elevation of kinase activity of LRRK2 that frequently accompanies its mutations is widely thought to contribute to its toxicity. Accordingly, many groups have developed LRRK2-specific kinase inhibit...

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Detalhes bibliográficos
Publicado no:Neuromolecular Med
Main Authors: Sim, Joan Poh Ling, Ziyin, Wang, Basil, Adeline Henry, Lin, Shuping, Chen, Zhongcan, Zhang, Chengwu, Zeng, Li, Cai, Yu, Lim, Kah-Leong
Formato: Artigo
Idioma:Inglês
Publicado em: Springer US 2019
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Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7230064/
https://ncbi.nlm.nih.gov/pubmed/31664682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12017-019-08577-z
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