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Chromothripsis and telomere crisis: engines of genome instability
In the early stages of carcinogenesis many cells confront two key suppressive checkpoints, senescence and telomere crisis. Crisis is characterized by massive chromosomal instability and cell death. The genetic instability initiated during crisis leaves detectable scars on cancer genomes, the full sc...
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| Published in: | Curr Opin Genet Dev |
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| Main Author: | |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2020
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7230029/ https://ncbi.nlm.nih.gov/pubmed/32151946 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.gde.2020.02.009 |
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