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Biosynthetic Incorporation of Site-Specific Isotopes in β-Lactam Antibiotics Enables Biophysical Studies

A biophysical understanding of the mechanistic, chemical, and physical origins underlying antibiotic action and resistance is vital to the discovery of novel therapeutics and the development of strategies to combat the growing emergence of antibiotic resistance. The site-specific introduction of sta...

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Publicat a:ACS Chem Biol
Autors principals: Kozuch, Jacek, Schneider, Samuel H., Boxer, Steven G.
Format: Artigo
Idioma:Inglês
Publicat: 2020
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7229998/
https://ncbi.nlm.nih.gov/pubmed/32175720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.9b01054
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