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Biosynthetic Incorporation of Site-Specific Isotopes in β-Lactam Antibiotics Enables Biophysical Studies

A biophysical understanding of the mechanistic, chemical, and physical origins underlying antibiotic action and resistance is vital to the discovery of novel therapeutics and the development of strategies to combat the growing emergence of antibiotic resistance. The site-specific introduction of sta...

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Bibliographic Details
Published in:ACS Chem Biol
Main Authors: Kozuch, Jacek, Schneider, Samuel H., Boxer, Steven G.
Format: Artigo
Language:Inglês
Published: 2020
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7229998/
https://ncbi.nlm.nih.gov/pubmed/32175720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.9b01054
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