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Biosynthetic Incorporation of Site-Specific Isotopes in β-Lactam Antibiotics Enables Biophysical Studies

A biophysical understanding of the mechanistic, chemical, and physical origins underlying antibiotic action and resistance is vital to the discovery of novel therapeutics and the development of strategies to combat the growing emergence of antibiotic resistance. The site-specific introduction of sta...

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Pubblicato in:ACS Chem Biol
Autori principali: Kozuch, Jacek, Schneider, Samuel H., Boxer, Steven G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7229998/
https://ncbi.nlm.nih.gov/pubmed/32175720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.9b01054
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