Enabling large-scale genome editing at repetitive elements by reducing DNA nicking

To extend the frontier of genome editing and enable editing of repetitive elements of mammalian genomes, we made use of a set of dead-Cas9 base editor (dBE) variants that allow editing at tens of thousands of loci per cell by overcoming the cell death associated with DNA double-strand breaks and sin...

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Veröffentlicht in:Nucleic Acids Res
Hauptverfasser: Smith, Cory J, Castanon, Oscar, Said, Khaled, Volf, Verena, Khoshakhlagh, Parastoo, Hornick, Amanda, Ferreira, Raphael, Wu, Chun-Ting, Güell, Marc, Garg, Shilpa, Ng, Alex H M, Myllykallio, Hannu, Church, George M
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2020
Schlagworte:
Synthetic Biology and Bioengineering
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7229841/
https://ncbi.nlm.nih.gov/pubmed/32315033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa239
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