Expanding the editable genome and CRISPR–Cas9 versatility using DNA cutting-free gene targeting based on in trans paired nicking

Genome editing typically involves recombination between donor nucleic acids and acceptor genomic sequences subjected to double-stranded DNA breaks (DSBs) made by programmable nucleases (e.g. CRISPR–Cas9). Yet, nucleases yield off-target mutations and, most pervasively, unpredictable target allele di...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Chen, Xiaoyu, Tasca, Francesca, Wang, Qian, Liu, Jin, Janssen, Josephine M, Brescia, Marcella D, Bellin, Milena, Szuhai, Karoly, Kenrick, Josefin, Frock, Richard L, Gonçalves, Manuel A F V
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Synthetic Biology and Bioengineering
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6954423/
https://ncbi.nlm.nih.gov/pubmed/31799604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz1121
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