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Alpha-cell dysfunctions and molecular alterations in male insulinopenic diabetic mice are not completely corrected by insulin

Glucagon and α-cell dysfunction are critical in the development of hyperglycemia during diabetes both in humans and rodents. We hypothesized that α-cell dysfunction leading to dysregulated glucagon secretion in diabetes is due to both a lack of insulin and intrinsic defects. To characterize α-cell d...

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Detalhes bibliográficos
Publicado no:Endocrinology
Main Authors: Dusaulcy, Rodolphe, Handgraaf, Sandra, Heddad-Masson, Mounia, Visentin, Florian, Vesin, Christian, Reimann, Franck, Gribble, Fiona, Philippe, Jacques, Gosmain, Yvan
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7228809/
https://ncbi.nlm.nih.gov/pubmed/26696123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2015-1725
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