Functional and molecular adaptations of enteroendocrine L-cells in male obese mice are associated with preservation of pancreatic alpha-cells function and prevention of hyperglycemia

Glucose homeostasis depends on the coordinated secretion of glucagon, insulin and GLP-1 by pancreas and intestine. Obesity which is associated with an increased risk of developing insulin resistance and type 2 diabetes affects the function of these organs. Here we investigate the functional and mole...

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Pubblicato in:Endocrinology
Autori principali: Dusaulcy, Rodolphe, Handgraaf, Sandra, Skarupelova, Svetlana, Visentin, Florian, Vesin, Christian, Heddad-Masson, Mounia, Reimann, Frank, Gribble, Fiona, Philippe, Jacques, Gosmain, Yvan
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7228810/
https://ncbi.nlm.nih.gov/pubmed/27547850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2016-1433
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