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Pax6 Is Crucial for β-Cell Function, Insulin Biosynthesis, and Glucose-Induced Insulin Secretion

The Pax6 transcription factor is crucial for endocrine cell differentiation and function. Indeed, mutations of Pax6 are associated with a diabetic phenotype and a drastic decrease of insulin-positive cell number. Our aim was to better define the β-cell Pax6 transcriptional network and thus provide f...

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Bibliografiska uppgifter
I publikationen:Mol Endocrinol
Huvudupphovsmän: Gosmain, Yvan, Katz, Liora S., Masson, Mounia Heddad, Cheyssac, Claire, Poisson, Caroline, Philippe, Jacques
Materialtyp: Artigo
Språk:Inglês
Publicerad: Endocrine Society 2012
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5417143/
https://ncbi.nlm.nih.gov/pubmed/22403172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2011-1256
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