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The β-cell specific transcription factor Nkx6.1 inhibits glucagon gene transcription by interfering with Pax6
The transcription factor Nkx6.1 is required for the establishment of functional insulin-producing β-cells in the endocrine pancreas. Overexpression of Nkx6.1 has been shown to inhibit glucagon gene expression while favouring insulin gene activation. Down-regulation resulted in the opposite effect, s...
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| Autori principali: | , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Portland Press Ltd.
2007
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1876377/ https://ncbi.nlm.nih.gov/pubmed/17263687 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20070053 |
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