Peroxiredoxin 4 Improves Insulin Biosynthesis and Glucose-induced Insulin Secretion in Insulin-secreting INS-1E Cells

Oxidative folding of (pro)insulin is crucial for its assembly and biological function. This process takes place in the endoplasmic reticulum (ER) and is accomplished by protein disulfide isomerase and ER oxidoreductin 1β, generating stoichiometric amounts of hydrogen peroxide (H(2)O(2)) as byproduct...

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Bibliografiska uppgifter
Huvudupphovsmän: Mehmeti, Ilir, Lortz, Stephan, Elsner, Matthias, Lenzen, Sigurd
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2014
Ämnen:
Protein Structure and Folding
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4175331/
https://ncbi.nlm.nih.gov/pubmed/25122762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.568329
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