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Peroxiredoxin 4 Improves Insulin Biosynthesis and Glucose-induced Insulin Secretion in Insulin-secreting INS-1E Cells

Oxidative folding of (pro)insulin is crucial for its assembly and biological function. This process takes place in the endoplasmic reticulum (ER) and is accomplished by protein disulfide isomerase and ER oxidoreductin 1β, generating stoichiometric amounts of hydrogen peroxide (H(2)O(2)) as byproduct...

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Bibliografske podrobnosti
Main Authors:	Mehmeti, Ilir, Lortz, Stephan, Elsner, Matthias, Lenzen, Sigurd
Format:	Artigo
Jezik:	Inglês
Izdano:	American Society for Biochemistry and Molecular Biology 2014
Teme:	Protein Structure and Folding
Online dostop:	https://ncbi.nlm.nih.gov/pmc/articles/PMC4175331/ https://ncbi.nlm.nih.gov/pubmed/25122762 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.568329
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Peroxiredoxin 4 Improves Insulin Biosynthesis and Glucose-induced Insulin Secretion in Insulin-secreting INS-1E Cells

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