Inter-domain dynamics drive cholesterol transport by NPC1 and NPC1L1 proteins

Transport of LDL-derived cholesterol from lysosomes into the cytoplasm requires NPC1 protein; NPC1L1 mediates uptake of dietary cholesterol. We introduced single disulfide bonds into NPC1 and NPC1L1 to explore the importance of inter-domain dynamics in cholesterol transport. Using a sensitive method...

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Enregistré dans:
Détails bibliographiques
Publié dans:eLife
Auteurs principaux: Saha, Piyali, Shumate, Justin L, Caldwell, Jenna G, Elghobashi-Meinhardt, Nadia, Lu, Albert, Zhang, Lichao, Olsson, Niclas E, Elias, Joshua E, Pfeffer, Suzanne R
Format: Artigo
Langue:Inglês
Publié: eLife Sciences Publications, Ltd 2020
Sujets:
Biochemistry and Chemical Biology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7228765/
https://ncbi.nlm.nih.gov/pubmed/32410728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.57089
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