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Inter-domain dynamics drive cholesterol transport by NPC1 and NPC1L1 proteins
Transport of LDL-derived cholesterol from lysosomes into the cytoplasm requires NPC1 protein; NPC1L1 mediates uptake of dietary cholesterol. We introduced single disulfide bonds into NPC1 and NPC1L1 to explore the importance of inter-domain dynamics in cholesterol transport. Using a sensitive method...
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| 出版年: | eLife |
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| 主要な著者: | , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
eLife Sciences Publications, Ltd
2020
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7228765/ https://ncbi.nlm.nih.gov/pubmed/32410728 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.57089 |
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