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A Phase I Trial of Enzastaurin in Patients with Recurrent Gliomas

PURPOSE: Enzastaurin is a selective inhibitor of protein kinase C β. Prior phase I studies did not show increased drug exposures with escalating once daily administration. Limits from gastrointestinal absorption may be overcome by twice daily dosing, potentially improving antitumor effects. EXPERIME...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Clin Cancer Res
Päätekijät: Kreisl, Teri N., Kim, Lyndon, Moore, Kraig, Duic, Paul, Kotliarova, Svetlana, Walling, Jennifer, Musib, Luna, Thornton, Donald, Albert, Paul S., Fine, Howard A.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2009
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7227612/
https://ncbi.nlm.nih.gov/pubmed/19417015
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-08-3071
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