Phase III Study of Enzastaurin Compared With Lomustine in the Treatment of Recurrent Intracranial Glioblastoma

PURPOSE: This phase III open-label study compared the efficacy and safety of enzastaurin versus lomustine in patients with recurrent glioblastoma (WHO grade 4). PATIENTS AND METHODS: Patients were randomly assigned 2:1 to receive 6-week cycles of enzastaurin 500 mg/d (1,125-mg loading dose, day 1) o...

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Detalhes bibliográficos
Main Authors: Wick, Wolfgang, Puduvalli, Vinay K., Chamberlain, Marc C., van den Bent, Martin J., Carpentier, Antoine F., Cher, Lawrence M., Mason, Warren, Weller, Michael, Hong, Shengyan, Musib, Luna, Liepa, Astra M., Thornton, Donald E., Fine, Howard A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Clinical Oncology 2010
Assuntos:
Original Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2834468/
https://ncbi.nlm.nih.gov/pubmed/20124186
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2009.23.2595
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