BRD4 Inhibition Protects Against Acute Pancreatitis Through Restoring Impaired Autophagic Flux

Impaired autophagy has been shown to play a critical role in experimental and human acute pancreatitis (AP). However, the mechanism for transcriptional regulation of autophagy remains largely unknown. In this study, we aim to explore the role of BRD4 (bromodomain-containing protein 4), a transcripti...

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Bibliographische Detailangaben
Veröffentlicht in:Front Pharmacol
Hauptverfasser: Shen, Shuangjun, Li, Bin, Dai, Juanjuan, Wu, Zengkai, He, Yan, Wen, Li, Wang, Xingpeng, Hu, Guoyong
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2020
Schlagworte:
Pharmacology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7227015/
https://ncbi.nlm.nih.gov/pubmed/32457617
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.00618
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