Acid Sphingomyelinase Downregulation Enhances Mitochondrial Fusion and Promotes Oxidative Metabolism in a Mouse Model of Melanoma

Melanoma is the most severe type of skin cancer. Its unique and heterogeneous metabolism, relying on both glycolysis and oxidative phosphorylation, allows it to adapt to disparate conditions. Mitochondrial function is strictly interconnected with mitochondrial dynamics and both are fundamental in tu...

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Veröffentlicht in:Cells
Hauptverfasser: Coazzoli, Marco, Napoli, Alessandra, Roux-Biejat, Paulina, De Palma, Clara, Moscheni, Claudia, Catalani, Elisabetta, Zecchini, Silvia, Conte, Vincenzo, Giovarelli, Matteo, Caccia, Sonia, Procacci, Patrizia, Cervia, Davide, Clementi, Emilio, Perrotta, Cristiana
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7226741/
https://ncbi.nlm.nih.gov/pubmed/32244541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells9040848
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