Nitric Oxide Generated by Tumor-Associated Macrophages Is Responsible for Cancer Resistance to Cisplatin and Correlated With Syntaxin 4 and Acid Sphingomyelinase Inhibition

Tumor microenvironment is fundamental for cancer progression and chemoresistance. Among stromal cells tumor-associated macrophages (TAMs) represent the largest population of infiltrating inflammatory cells in malignant tumors, promoting their growth, invasion, and immune evasion. M2-polarized TAMs a...

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Udgivet i:Front Immunol
Main Authors: Perrotta, Cristiana, Cervia, Davide, Di Renzo, Ilaria, Moscheni, Claudia, Bassi, Maria Teresa, Campana, Lara, Martelli, Cristina, Catalani, Elisabetta, Giovarelli, Matteo, Zecchini, Silvia, Coazzoli, Marco, Capobianco, Annalisa, Ottobrini, Luisa, Lucignani, Giovanni, Rosa, Patrizia, Rovere-Querini, Patrizia, De Palma, Clara, Clementi, Emilio
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2018
Fag:
Immunology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5987706/
https://ncbi.nlm.nih.gov/pubmed/29896202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.01186
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