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Long-Distance Phasing of a Tentative “Enhancer” Single-Nucleotide Polymorphism With CYP2D6 Star Allele Definitions

BACKGROUND: The CYP2D6 gene locus has been extensively studied over decades, yet a portion of variability in CYP2D6 activity cannot be explained by known sequence variations within the gene, copy number variation, or structural rearrangements. It was proposed that rs5758550, located 116 kb downstrea...

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Publicat a:Front Pharmacol
Autors principals: Boone, Erin C., Wang, Wendy Y., Gaedigk, Roger, Cherner, Mariana, Bérard, Anick, Leeder, J. Steven, Miller, Neil A., Gaedigk, Andrea
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2020
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7226225/
https://ncbi.nlm.nih.gov/pubmed/32457600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.00486
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