Identification of Novel CYP2D7-2D6 Hybrids: Non-Functional and Functional Variants

Polymorphic expression of CYP2D6 contributes to the wide range of activity observed for this clinically important drug metabolizing enzyme. In this report we describe novel CYP2D7/2D6 hybrid genes encoding non-functional and functional CYP2D6 protein and a CYP2D7 variant that mimics a CYP2D7/2D6 hyb...

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Bibliographic Details
Main Authors: Gaedigk, Andrea, Jaime, Lazara Karelia Montane, Bertino, Joseph S., Bérard, Anick, Pratt, Victoria M., Bradfordand, L. DiAnne, Leeder, J. Steven
Format: Artigo
Language:Inglês
Published: Frontiers Research Foundation 2010
Subjects:
Pharmacology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3153001/
https://ncbi.nlm.nih.gov/pubmed/21833166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2010.00121
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