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Strained Conformations of Nucleosides in Active Sites of Nucleoside Phosphorylases

Nucleoside phosphorylases catalyze the reversible phosphorolysis of nucleosides to heterocyclic bases, giving α-d-ribose-1-phosphate or α-d-2-deoxyribose-1-phosphate. These enzymes are involved in salvage pathways of nucleoside biosynthesis. The level of these enzymes is often elevated in tumors, wh...

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Publicat a:Biomolecules
Autors principals: Il’icheva, Irina A., Polyakov, Konstantin M., Mikhailov, Sergey N.
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2020
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7226091/
https://ncbi.nlm.nih.gov/pubmed/32260512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biom10040552
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