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Active Site Conformational Dynamics in Human Uridine Phosphorylase 1
Uridine phosphorylase (UPP) is a central enzyme in the pyrimidine salvage pathway, catalyzing the reversible phosphorolysis of uridine to uracil and ribose-1-phosphate. Human UPP activity has been a focus of cancer research due to its role in activating fluoropyrimidine nucleoside chemotherapeutic a...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2939078/ https://ncbi.nlm.nih.gov/pubmed/20856879 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0012741 |
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