STAT5 is Expressed in CD34(+)/CD38(−) Stem Cells and Serves as a Potential Molecular Target in Ph-Negative Myeloproliferative Neoplasms

Janus kinase 2 (JAK2) and signal transducer and activator of transcription-5 (STAT5) play a key role in the pathogenesis of myeloproliferative neoplasms (MPN). In most patients, JAK2 V617F or CALR mutations are found and lead to activation of various downstream signaling cascades and molecules, incl...

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Detalhes bibliográficos
Publicado no:Cancers (Basel)
Main Authors: Hadzijusufovic, Emir, Keller, Alexandra, Berger, Daniela, Greiner, Georg, Wingelhofer, Bettina, Witzeneder, Nadine, Ivanov, Daniel, Pecnard, Emmanuel, Nivarthi, Harini, Schur, Florian K. M., Filik, Yüksel, Kornauth, Christoph, Neubauer, Heidi A., Müllauer, Leonhard, Tin, Gary, Park, Jisung, de Araujo, Elvin D., Gunning, Patrick T., Hoermann, Gregor, Gouilleux, Fabrice, Kralovics, Robert, Moriggl, Richard, Valent, Peter
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7225958/
https://ncbi.nlm.nih.gov/pubmed/32326377
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers12041021
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