Lung penetration, bronchopulmonary pharmacokinetic/pharmacodynamic profile and safety of 3 g of ceftolozane/tazobactam administered to ventilated, critically ill patients with pneumonia

OBJECTIVES: Ceftolozane/tazobactam is approved for hospital-acquired/ventilator-associated bacterial pneumonia at double the dose (i.e. 2 g/1 g) recommended for other indications. We evaluated the bronchopulmonary pharmacokinetic/pharmacodynamic profile of this 3 g ceftolozane/tazobactam regimen in...

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Detalhes bibliográficos
Publicado no:J Antimicrob Chemother
Main Authors: Caro, Luzelena, Nicolau, David P, De Waele, Jan J, Kuti, Joseph L, Larson, Kajal B, Gadzicki, Elaine, Yu, Brian, Zeng, Zhen, Adedoyin, Adedayo, Rhee, Elizabeth G
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
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Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7225904/
https://ncbi.nlm.nih.gov/pubmed/32211756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dkaa049
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