Modeling Breast Cancer Using CRISPR-Cas9–Mediated Engineering of Human Breast Organoids

Breast cancer is characterized by histological and functional heterogeneity, posing a clinical challenge for patient treatment. Emerging evidence suggests that the distinct subtypes reflect the repertoire of genetic alterations and the target cell. However, the precise initiating events that predisp...

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Dades bibliogràfiques
Publicat a:J Natl Cancer Inst
Autors principals: Dekkers, Johanna F, Whittle, James R, Vaillant, François, Chen, Huei-Rong, Dawson, Caleb, Liu, Kevin, Geurts, Maarten H, Herold, Marco J, Clevers, Hans, Lindeman, Geoffrey J, Visvader, Jane E
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2019
Matèries:
Brief Communication
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7225674/
https://ncbi.nlm.nih.gov/pubmed/31589320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jnci/djz196
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