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Jekyll or Hyde: does Matrigel provide a more or less physiological environment in mammary repopulating assays?

In vivo transplantation is the current 'gold-standard' assay for evaluating mammary stem cell (MaSC) function. Matrigel, a reconstituted extracellular matrix derived from a mouse sarcoma line, is increasingly being utilized for mammary repopulating assays, although original studies were ca...

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Bibliographic Details
Main Authors: Vaillant, François, Lindeman, Geoffrey J, Visvader, Jane E
Format: Artigo
Language:Inglês
Published: BioMed Central 2011
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3218928/
https://ncbi.nlm.nih.gov/pubmed/21635708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/bcr2851
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