Berberine Improves Glucose and Lipid Metabolism in HepG2 Cells Through AMPKα1 Activation

AIM: This study is designed to investigate whether or not AMP-activated protein kinase α1 (AMPKα1) is required for natural product berberine (BBR) to improve glucose and lipid metabolism in HepG2 cells. METHODS: AMPKα1 knocked-out (KO, AMPKα1(-/-)) cells were obtained by co-transfection of the CRISP...

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Bibliographische Detailangaben
Veröffentlicht in:Front Pharmacol
Hauptverfasser: Ren, Gang, Guo, Jiang-Hong, Qian, Yu-Zhen, Kong, Wei-Jia, Jiang, Jian-Dong
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2020
Schlagworte:
Pharmacology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7225256/
https://ncbi.nlm.nih.gov/pubmed/32457629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.00647
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