Berberine Improves Glucose and Lipid Metabolism in HepG2 Cells Through AMPKα1 Activation

AimThis study is designed to investigate whether or not AMP-activated protein kinase α1 (AMPKα1) is required for natural product berberine (BBR) to improve glucose and lipid metabolism in HepG2 cells.MethodsAMPKα1 knocked-out (KO, AMPKα1-/-) cells were obtained by co-transfection of the CRISPR/Cas9...

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Main Authors: Gang Ren, Jiang-Hong Guo, Yu-Zhen Qian, Wei-Jia Kong, Jian-Dong Jiang
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020-05-01
Colecção:Frontiers in Pharmacology
Assuntos:
berberine
AMP-activated protein kinase α1
glucose consumption
gluconeogenesis
lipogenesis
Acesso em linha:https://www.frontiersin.org/article/10.3389/fphar.2020.00647/full
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