CHK1 dosage in germinal center B cells controls humoral immunity

Germinal center (GC) B cells are among the fastest replicating cells in our body, dividing every 4–8 h. DNA replication errors are intrinsically toxic to cells. How GC B cells exert control over the DNA damage response while introducing mutations in their antibody genes is poorly understood. Here, w...

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Udgivet i:Cell Death Differ
Main Authors: Schoeler, Katia, Jakic, Bojana, Heppke, Julia, Soratroi, Claudia, Aufschnaiter, Andreas, Hermann-Kleiter, Natascha, Villunger, Andreas, Labi, Verena
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7224292/
https://ncbi.nlm.nih.gov/pubmed/30894677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-019-0318-5
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