A conjugated mTOR/MEK bifunctional inhibitor as potential polypharmacological anticancer agent: the prototype compound discovery

mTOR/MEK bifunctional inhibitors have the potential to surmount the drug resistance aroused from cross talk between PI3K/Akt/mTOR (PAM) and Ras/MEK/ERK pathways. Herein, we report the discovery of a conjugated dual-targeted molecule, compound 13, as the prototype mTOR/MEK bifunctional inhibitor. It...

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Bibliographische Detailangaben
Veröffentlicht in:Med Chem Res
Hauptverfasser: Tao, Qiangqiang, Fang, Fang, Li, Jiaming, Wang, Yong, Zhao, Can, Liang, Jingtai, Ma, Xiaodong, Wang, Hao
Format: Artigo
Sprache:Inglês
Veröffentlicht: Springer US 2020
Schlagworte:
Original Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7223898/
https://ncbi.nlm.nih.gov/pubmed/32435126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00044-020-02502-x
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